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Infertility and Tuberculosis

Tuesday 23 January 2018

Infertility and Tuberculosis

Getting conceived is like a blessing for women, but this is not the case for most of the women as they face trouble with infertile problems. And the most common cause of infertility particularly in underdeveloped nations is Tuberculosis. Whereas, this is not that much pronounced case in developed countries. One may seems to be healthy, have regular menstruation cycle, regular exercising habit, proper diet, and no overweight but they are not able to conceive. Even though, TB has become less common in today’s environment, people who are facing this issue will suffer from a lot of distress and sorrow.

How TB creates impact on infertility?

This is the disease that is caused by tubercle bacillus. This is happened when there occurs infection in the genital tract. In women, this infection leads to endometriosis (uterus infection), salpingitis (infection in the fallopian tubes) and tuberculosis. Women have face this infection have no prior indications or symptoms at all. Genital TB is a kind of disease that can’t be treated soon because it is like a hushed invader of the genital tract. 

The common ways of providing a diagnosis for this is by culturing the tubercle bacillus from tissue sampled from the genital tract. As it is the complicated situation to take tissue from the fallopian tubes, the diagnosis is done by observing the tubercle bacilli in the endometrial tissue that is gathered from uterine curettage.

This kind of curettage is a simple way to accomplish and in general developing bacillus in the laboratory, still in women who are with frank genital TB can be very tough, since this is a very temperamental bacillus that develops very slowly in the microbiology lab. As because of this reason, only few doctors recommend and mostly rely on indirect support to pushover the diagnosis.

As this is the most complicated situation to find the disorder, doctors usually start their treatment with antiTB course that stops further development of the disease. In past days, doctors try to perform surgery to resolve the problem with fallopian tubes, but this is somewhat seems to be unsuccessful, so they have to go with another scenario. 

Once the course of antiTB has started there is no sign for the growth of the disease as the medication with antiTB kills the bacilli cells. The most popular tests for finding this “silent TB” is uses 'reproductive molecular immunology' techniques for PAMP ( pathogen-associated molecular pattern ) for immunopathological assessment.

Moreover, this can also be treated with LIT (Lymphocyte immune theraphy) where The HLA antigens on the placenta cells collected by the father are termed as HLA-G. When there happens sharing of DQ alpha antigens in common, the G molecule put on the placental cells by the father is too analogous to the G molecule that the woman’s father put on her placenta to carry on in the mother’s uterus.

So, go with the proper treatment for this disease and stay away from all the disorders that lead to infertility.