In today’s fast life infertility is a cause of worry for many couples. Besides the lifestyle and eating habits, scientific research stresses that smoking hits hard on the fertility of both men and women. While smoking does permanent damage to the heart, triggers cancer, lungs also it impacts the sperm motility, semen quality, count and causes several other health related issues which contributes 30% to the unexplained fertility in men. The toxins from the cigarette take a huge troll on the health and the entire body, including the male reproductive system. This article summarizes the harmful effects of smoking and how it impacts the fertility in men.