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oocyte cryopreservation

Oocyte Cryopreservation - Egg Freezing Process

EGG,Oocyte Cryopreservation, Egg freezing Treatment at SWCIC

Oocyte cryopreservation is done particularly in conditions where women suffer with chronic illness such as cancer or who are about to undergo chemotherapy. The procedure is done to preserve the egg similar to the IVF treatment.

Egg/Oocyte (Freezing) Cryopreservation
Egg/ Oocyte Freezing has already registered its position in the front line of the global infertility treatment styles. We SWCIC- the best IVF center in Hyderabad India helps you in preserving your fertiliy for future through this. Go through the details below.
What is Egg Freezing?
  • Egg freezing is also known as oocyte cryopreservation. This egg freezing method is used to save woman ability to get pregnant in future. Eggs are collected from your ovaries and stored them in a lab. A frozen egg can be combined with sperm in a lab and is placed in woman’s uterus. The fertility doctor can help you to understand how this egg freezing works.
ASRM GUIDELINE 2013
  • Evidence indicates that oocyte vitrification and warming should no longer be considered experimental Human oocyte cryopreservation (egg freezing) is a process in which a woman’s eggs (oocytes) are extracted, frozen and stored. Later, when she is ready to become pregnant, the eggs can be thawed, fertilized, and transferred to the uterus as embryos.
Oocyte cryopreservation is aimed at three particular groups of women
  • Women with cancer who have not yet begun chemotherapy or radiotherapy (Chemotherapy and radiotherapy are toxic for oocytes, leaving few, if any, viable eggs. Egg freezing offers women with cancer the chance to preserve their eggs so that they can have children in the future.)
  • Those who would like to preserve their future ability to have children, either because they do not yet have a partner, or for other personal or medical reasons (e.g.: Late marriage or having a family history of Premature ovarian failure/Early menopause (40 yrs.)
  • Egg freezing can also be beneficial for women who, for the purpose of education, career or other reasons, desire to postpone childbearing. Freezing eggs at an early age may ensure a chance for a future pregnancy.
PROCEDURE
  • The egg retrieval process for oocyte cryopreservation is the same as that for in vitro fertilization. This includes hormone injections that stimulate ovaries to ripen multiple eggs. When the eggs are mature, final maturation induction is performed, preferably by human chorionic gonadotropin (hCG). The eggs are subsequently removed from the body by transvaginal oocyte retrieval. The procedure is usually conducted under sedation. The eggs are immediately frozen.
  • The egg is the largest cell in the human body and contains a high amount of water. When the egg is frozen, the ice crystals that form can destroy the integrity of the cell. To prevent this, the egg must be dehydrated prior to freezing. This is done using cryoprotectants which replace most of the water within the cell and inhibit the formation of ice crystals.
  • Eggs (oocytes) are frozen using the newer flash-freezing process known as vitrification. Vitrification is much faster but requires higher concentrations of cryoprotectants to be added. The result of vitrification is a solid glass-like cell, free of ice crystals.
  • Vitrification is associated with higher survival rates and better development compared to slow-cooling when applied to oocytes in metaphase II (MII).
  • During the freezing process, the zona pellucida, or shell of the egg can be modified preventing fertilization. Thus, currently, when eggs are thawed, a special fertilization procedure is performed by an embryologist called ICSI (Intracytoplasmic Sperm Injection) and is also used in IVF.
Why is Egg Freezing Treatment Done?
  • If you are not ready to become pregnant now and want to make pregnant in the future, then egg freezing is a good option.
  • Unlike embryo cryopreservation (Fertilized egg freezing), egg freezing doesn’t require a sperm because the eggs are stored in a lab and didn’t fertilized. You need to take fertility drugs to make you ovulate to produce multiple eggs for egg retrieval.
  • You will consider egg freezing if:
    • 1. You have a condition that can affect your fertility. These should include autoimmune diseases such as lupus, sickle cell anemia, being transgender, gender diversity.
    • 2. You need treatment for cancer and other diseases that can affect your fertility. Certain medications such as chemotherapy or radiation can harm your fertility. Egg freezing treatment will help you to get biological children later.
    • 3. You are undergoing IVF (in Vitro Fertilization). Some people prefer oocyte cryopreservation to embryo cryopreservation for ethical or religious reasons.
    • 4. You wish to preserve younger eggs for your future use. Freezing eggs at an younger age will improve the chances of success in getting pregnant whenever you are ready.
  • You can use your eggs to conceive a baby with your partner’s sperm or donor sperm. The embryo can also be implanted in another woman’s uterus to carry the pregnancy (gestational carrier).
Risks in Egg Freezing
  • Usage of fertility drugs such as luteinizing hormone (LH) or synthetic follicle-stimulating hormone (FSH) to induce ovulation can affect your ovaries to become swollen and painful after the retrieval of egg quality or ovulation. The signs and symptoms include vomiting, bloating, abdominal pain, vomiting, nausea, and diarrhea.
  • Use an aspiring needle to collect the eggs will cause bowel damage, infection, and bleeding.
  • Egg freezing can give hope to future pregnancy but there is no guaranteed success.
What you can expect
  • Multiple steps are involved in the egg freezing process. They are ovarian stimulation, egg retrieval, and freezing.
Ovarian Stimulation
  • The Woman takes synthetic hormones to produce more eggs. The medications need for egg retrieval are:
  • Medications for ovarian stimulation: You should take medication such as Beta or Alfa or menotropins.
  • Medications to prevent premature ovulation: The fertility specialist can give the injectable gonadotropin-releasing hormone antagonist such as Lupron (leuproline acetate) or gonadotropin-releasing hormone antagonist such as Cetrotide (cetrorelix).
  • The doctor didn’t monitor the patient during treatment. They suggest a blood test to know your response to ovarian stimulation medications. Progesterone levels are low until after ovulation and estrogen levels increase the follicle development.
  • A procedure called ultrasounds can be done to see the image of the inside ovaries to monitor the eggs mature.
  • When the follicles are ready for retrieval of eggs, an human chorionic gonadotropin injection or another medication that increase the egg development.
Egg Retrieval
  • Egg retrieval is done in a fertility clinic or a hospital. An ultrasound probe is inserted into your uterus to identify the follicles.
  • A needle is guided through the uterus and then a follicle. A suction device is used to connect with the needle is used to separate the egg from the follicles. Multiple eggs are retrieved up to 8 to 15 eggs for the better chance of birth.
  • After the egg retrieval, you feel fullness due to the enlargement of your ovaries.
Freezing
  • After that, the eggs are cooling in subzero temperature. The process used for egg freezing is called vitrification. High concentrations of substances are used to help to prevent the formation of ice crystals.
Egg Freezing Success Rates
  • When you want to use your frozen eggs, they are unfrozen, fertilize with sperm and placed it in your uterus.
  • The doctor will recommend a fertilization technique called ICSI (intracytoplasmic sperm injection). In the ICSI process, a single sperm is inserted directly into a mature egg.
  • The success rates of egg freezing are roughly 30 to 60% depending on the person’s age at the time of egg freezing cycle.
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